The 36-year-old Spaniard, who is currently AC Milan's backup for Gianluigi Donnarumma, was found to have the best ratio of matches to clean sheets of any keeper with more than 50 appearances in Premier League history.
FourFourTwo revealed the top 20. Reina kept a clean sheet in 47.02% of his matches, while Petr Cech was good enough for silver with a rate of 45.68% in his matches for Chelsea and Arsenal.
Edwin van der Sar rounds out the top three, with a percentage of 42.17% for Manchester United and Fulham.
Also making it into the top five are Danish legend Peter Schmeichel (41.29%) and Arsenal legend David Seaman (40.70%).
Tottenham and Chelsea's Italian keeper Carlo Cudicini kept 64 clean sheets in 161 games, handing him a ratio of 39.75%.
David De Gea, arguably the best keeper in the Premier League today, only manages a percentage of 39.00%, while the next best current keeper is Joe Hart, with 38.15%.