The centre-back was sent off for the first and only time in his Real Madrid career against Athletic, at the Santiago Bernabeu.
It was February 13, 2016, and 'Los Blancos' hosted Athletic, who were at that time managed by Ernesto Valverde, in a game that was essentially irrelevant due to the huge gap in points between them and Barcelona.
Varane was part of a back four that included Sergio Ramos, Dani Carvajal and Danilo, but he had to make the walk down the tunnel in the 83rd minute, after seeing his second yellow card of the game.
Alfonso Alvarez was the referee who showed the Frenchman his first red, after booking him in the 16th minute of the clash. He had never previously been dismissed, neither in La Liga or Ligue 1, however his side managed without him, recording a 4-2 win.
Just over a year later, Varane was sent off for the second time, while playing in a friendly for France. This time, however, it was a straight red in the 47th minute, in a friendly that 'Les Bleus' won 3-2.
The defender will hope to banish these memories on Wednesday, as his side look to keep the pressure on Atletico for second place in La Liga.