Manchester City and United will meet on Sunday to contest a widely anticipated Manchester Derby.
Manchester United's impressive comeback against Juventus is a welcome boost ahead of the clash, a game that United shocked 3-2 in April.
"I don't like to compare situations," Herrera told 'Sky Sports'.
"It's a new game, a new situation. Hopefully, we can win.
"It's true that they are the favourites because they are in unbelievable form, but this is Manchester United and you never know what can happen."
"When you play for Manchester United, the biggest club in the UK and one of the biggest in the world, you have to get used to that," said Herrera.
"I have been here five years and with [Louis] Van Gaal every day the papers talking.
"When Mourinho came, the same and we won titles. One day if another manager comes, they will speak so it's something we are used to coping with.
"I think Manchester United players need to have the personality to cope with that. It's true when our Premier League opponents lose games, the papers don't talk that much, but when we lose, they do."