A seventh defeat in nine games further damaged United's chances of Champions League qualification, but they could still make the top four with Tottenham, Chelsea and Arsenal also faltering.
Manchester City - 89 points
The title remains in City's hands thanks to a run of 11 straight Premier League wins and victory at Old Trafford on Wednesday was a huge step towards becoming the first side to retain the Premier League in a decade.
A trip to Burnley on Sunday is followed by the visit of Leicester to the Etihad before City end the season at relegation-threatened Brighton.
City's Champions League elimination means they will have a full week to prepare for their final two league games.
Liverpool - 88 points
A run of nine consecutive wins in all competitions has helped keep Jurgen Klopp's men stay on City's coattails and in position to pounce should the champions suffer an unexpected stumble in their remaining three games.
A first top-flight title in 29 years was described by Klopp as the "holy grail" after Sunday's 2-0 win at Cardiff and even if they fall short, it has been a historic campaign for the Reds.
Liverpool already have more points than ever before in the Premier League era and they should comfortably add three more when relegated Huddersfield visit Anfield on Friday.
A tricky trip to Newcastle sandwiched between two Champions League semi-final clashes with Barcelona is a potential banana skin before they host Wolves on the final day of the season.