There had been a lot of talk in the build up to the game over Diego Costa's fitness, but the striker will have to settle for a place on the bench alongside Fernando Torres.
Kevin Gameiro will act as the foil to Antoine Griezmann up front but the rest of the Atletico team is more or less as you would expect.
The same can be said for Arsenal, as Mesut Ozil returns after sitting out at the weekend. Alexandre Lacazette will lead the line with Aubameyang cup-tied.
Full teams below:
Arsenal - Ospina, Bellerin, Mustafi, Koscielny, Monreal, Xhaka, Ramsey, Wilshere, Ozil, Welbeck, Lacazette
Atletico - Oblak, Vrsaljko, Giménez, Godín, Lucas, Correa, Thomas, Saúl, Koke, Griezmann, Gameiro