Juan Antonio Pizzi has no major absences in his Chile squad as they attempt to make it through to the final, despite only winning one game in the competition.
Portugal, on the other hand, will have to deal with Pepe's suspension after receiving another booking in their last group fixture. West Ham defender Jose Fonte will take his place.
Raphael Guerreiro is also out of the first semi-final after picking up an ankle injury in the group stages, with Eliseu stepping into the left-back position.
Good new for Fernando Santos is that Bernardo Silva seems to have recovered. Stars Cristiano Ronaldo and Alexis Sanchez are expected to start.
Portugal: Patricio, Soares, Alves, Fonte, Eliseu, Quaresma, Carvalho, Adrien Silva, Bernardo Silva, Ronaldo, Andre Silva.
Chile: Bravo, Isla, Jara, Diaz, Beausejour, Vidal, Aranguiz, Medel, Fuenzalida, Vargas, Sanchez.