Anghel Iordanescu has made four changes to the team which started against France in the opening game of the tournament.
Nicalae Stanciu, Ovidiu, Hoban, Adrian Popa and Florin Andone all drop to the bench, while Andrei Prepelita, Gabriel Torje, Alexandru Chipciu and Claudiu Keseru all gain a starting spot.
Perhaps unsurprisingly, Switzerland have made no changes from the side that beat Albania 1-0 on Saturday.
Romania XI (4-5-1): Tatarusanu, Rat, Chiriches, Grigore, Sapunaru, Prepelita, Pintilii, Torje, Stancu, Chipciu, Keseru
Subs: Pantilimon, Lung, Matel, Moti, Hoban, Alibec, Stanciu, Andone, Gaman, Filip, Samartean, Popa
Switzerland XI (4-5-1): Sommer, Lichsteiner, Schar, Djourou, Rodriguez, Behrami, Xhaka, Shaqiri, Dzemaili, Mehmedi, Seferovic
Subs: Moubandje, Burki, Derdiyok, Embolo, Fernandes, Tarashaj, Hitz, Lang, Von Bergen, Zakaria, Elvedi, Frei.