Luis Suarez is almost guaranteed to be unavailable for what's left of the season, and with Barcelona not signing any strikers this transfer window, Quique Setién has no choice but to get on with it.
But doing so might prove difficult, as Luis Suarez had been more influential than ever before up until his injury. The Uruguayan star had provided almost half of Barça's goals, and his goalscoring ability had been particularly effective on away games.
Barcelona's away form has left lot to be desired this campaign, but as Spanish sports newspaper 'AS' points out, it would have been much worse if Luis Suarez had not been present, often scoring the winner and providing assists.
Aditionally, he's also come to the rescue in other situations, scoring the equaliser in vital games that would have put Barcelona behind Real Madrid even earlier in the season.
Consulting our ProFootballDB data, in LaLiga, Suárez scored in the victory against Getafe (0-2), added another against Eibar (0-3), scored the opener against Leganés (1-2), gave an assist to Messi for the only goal against Atletico (0-1), scored and assisted against Real (2-2) and did the same against Espanyol.
He's also made a difference in the Champions League, giving in assist to Ansu Fati in the 1-2 win against Inter at the Meazza and participating in the play of the 1-2 against Slavia Prague.
And there's more bad news for Barcelona: when Luis Suarez did not participate successfully through goals or assists, Barcelona did not win. A serious problem for Barcelona's away form and eventually title hopes.