England ran away with the lead at Wembley against the Czechs after Raheem Sterling, along with some help from Czech defensive errors, helped himself to an international hat-trick for England.
The goals were testament to a strong England performance all-round, with Kane claiming a penalty earlier in the game, won by Sterling.
He was swiftly substituted for Callum Hudson-Odoi who made his much-anticipated England debut with 20 minutes left to play.