The north London side have been forced to move their Premier League clash with champions Manchester City to Monday October 29 due to a clash with an NFL fixture at Wembley, with the Jacksonville Jaguars due to play the Philadelphia Eagles on October 29.
Spurs are still playing their home games at the national stadium after delays in the construction of their new ground and they are expected to remain there for the forseeable future.
Mauricio Pochettino's side have already been forced to search for an alternative ground on one occasion this season after playing a game at MK Dons' Stadium MK and the inconvenience of moving the City game was confirmed on Thursday as it was announced that Spurs' EFL Cup clash with West Ham will take place just two days later on Wednesday October 31.
That is likely to put further strain on a squad that is already littered with injuries and spread thin due to their league, cup and Champions League commitments.