Sevilla: There are no new injury concerns for the home side, and Pablo Machin could even named an unchanged side from the one that hit six past Levante last weekend.
Real Madrid: Isco had his appendix removed on Tuesday afternoon and a date has not yet been set for his return to the side.
Machin: The most important people are the ones out on the pitch, but we've always said that the fans help and play as well. The fans are our twelfth man, and in days like tomorrow they'll be even more important to push us on to win. Whatever you do, Madrid will have chances. We have to be strong in our duels because they have a lot of strength and we have to try to prevent their quality from showing so that we can get the win. That's the plan, but during each game there are many different phases and we have to make the most of our own. I'm not sure it's a good idea to play your last card right from the off, especially when they were able to rest players this weekend. We have to see how our recovery has gone and I have an idea of it, but I need to see how everyone is and who can give us the best performance.
Lopetegui: We're facing a top side, with players who have instantly taken to Pablo Machín's approach. They can play a 5-3-2 or a 5-2-3. They make life hard for all their rivals and have been scoring plenty of goals. We are Real Madrid and we have to approach every game in the right way, with the right attitude. We're going to the Sánchez-Pizjuán and it is a fixture rich in history and complexities. That pushes us forward and excites us. The biggest motivation is to get three points against Sevilla. It will be a gruelling, draining game in a fortress of a stadium.
Did you know?
Real Madrid have won 76 of 144 games between the two sides, with 26 ending in a draw.
Score prediction: 2-2
Sevilla possible XI: Vaclik, Carrico, Kjaer, Comez, Vidal, Navas, Sarabia, Vazquez, Banega, Silva, Ben Yedder
Real possible XI: Courtois, Carvajal, Varane, Ramos, Marcelo, Casemiro, Modric, Kroos, Asensio, Bale, Benzema