After a 3-1 win at Nantes in their opener, Leonardo Jardim's principality outfit have now gone four league matches without a win and sit 15th in the early table on just five points.
With captain Radamel Falcao out with illness and the Colombian's fellow attackers Stevan Jovetic, Rony Lopes and Aleksandr Golovin all injured, Monaco started with 18-year-old Moussa Sylla up front at the Stadium de Toulouse.
"The players have given the maximum," said Jardim. "Absences? I don't complain about the absences. We are here to help the youngsters progress."
Monaco will now be hoping that their big guns can return in time for Tuesday's Champions League opener against Atletico Madrid at the Stade Louis II.
"For Tuesday against Atletico Madrid we'll need to keep this attitude and this behaviour, but be better technically," Portuguese coach Jardim added.
They did take a 57th-minute lead as Belgian international Youri Tielemans hammered a left-footed strike in off the crossbar from the edge of the box, but Toulouse deservedly took a point.
Leya Iseka, the younger brother of Belgium and Chelsea striker Michy Batshuayi, picked out the bottom corner in the 79th minute to score his first goal for the club since joining from Anderlecht in June.
The 20-year-old had impressed on loan at Zulte Waregem last season, scoring six goals in the Belgian top flight.
Monaco never threatened a winner, managing just two shots on target in the match.