Monaco edge away from relegation with Vinicius winner at Lille
The Brazilian scored his first goal for the Principality outfit since joining on-loan from Napoli in January as the hosts lost only for a second time at home in the league this campaign.
Coach Leonardo Jardim, who led his side to the title in 2017, sees Monaco go clear of Dijon in 18th place with their fourth win in seven games since he returned to the Stade Louis II in January.
"A victory like today against the second-best team in the championship is very important," said Jardim. "It's an important win, but we're still in a difficult situation."
The home side had the best of the early opportunities on goal as winger Jonathan Bamba hit the crossbar after 11 minutes with a left-footed effort.
Bamba and Nicolas Pepe both had shots on goal to break the deadlock before the break but wasted their chances in front of Monaco goalkeeper Danijel Subasic.
The visitors started the second half strongly as Aleksandr Golovin and Gelson Martins tested Mike Maignan before the 50-minute mark.
Vinicius' first goal in Monaco colours came as he received the ball in the box.
He took a deft touch with his toe to lift the ball over defender Jose Fonte, chested the ball down and slotted it past Maignan in the Lille goal.
Lille remain 17 points behind leaders Paris Saint-Germain, who host arch-rivals Marseille on Sunday.
Elsewhere on Friday, substitute Firmin Mubele clinched a 1-1 draw for Toulouse at Nice with an 89th-minute effort.
On Saturday, bottom-of-the-table Guingamp can close the gap on Dijon, Caen host Saint-Etienne, Angers face lowly Amiens and Strasbourg head to Nimes.