Speaking ahead of the clash, the former Barcelona manager said that Southgate had made England a dangerous opponent that Spain would be respectful of.
The last meeting between the sides ended in a 2-1 win for Spain at Wembley, but Enrique clearly still respects Southgate, who was recently rewarded by the FA for his work, signing a new contract.
'What gives us the mathematical classification is victory,' Enrique told a media conference on Sunday.
'We will try to overcome a very difficult opponent who is doing things very well.'
On the England manager, Enrique said: 'I like Southgate as a coach.
They always try to play the ball. He's adapted to his players, something we all have to do. I followed him and I like the way he plays football.
'He has just renewed (his contract, until 2022) and that means they trust him – and he has helped me learn English with his press conferences.'
England's potency from corners and free kicks was a big feature of their successful World Cup campaign and it is something Enrique was wary of, saying: 'We must be vigilant and ensure that we generate the least possible occasions (for set-pieces).'