Manchester United surprised everyone and took to the Etihad Stardium with a 1-2 win that left the English champions down for the count.
The unexpected defeat against Manchester rivals left City in third place and 14 points behind legaue leaders Liverpool, who seem unstoppable, something that has made Guardiola start to rule out winning the Premier League.
"It's normal that we don't always win the Premier League. They are times in which we will lose," the coach explained, despite sending a message of perseverance to his team.
"Whether we are 5, 10, 14 or 15 points behind we are going to keep fighting. If we are not able to win, we will do it next year. We cannot give up and we have to keep showing our game as a team,"
It has to be remembered that City have won the last two seasons of the Premier League, although everything indicates that Pep's team will not be able to achieve this a third time in a row.