Sergi Roberto also makes his return to the squad after serving out his suspension, and is highly likely to be included in Valverde's starting XI for the game.
Meanwhile, there is little surprise in those who have been omitted. Andre Gomes, Aleix Vidal, Lucas Digne and Yerry Mina will all be sitting the match out.
Barcelona have already claimed the league title, but are insistent that this 'El Clasico' will be just as important as those that have determined La Liga outcome in previous years.
Valverde's side are seeking to extend their unbeaten streak against Real Madrid to make history with 42-games undefeated.
May 5, 2018