Chelsea will hope to bounce back from a 3-0 loss at Roma during the Champions League in midweek. Antonio Conte's side currently sit in fourth place, four points behind Jose Mourinho's side.
United are in second place, five points behind league leaders Manchester City, and have won their last three games in all competitions without conceding.
The Blues have a good recent record against Sunday's opponents, having lost just once in their last 15 home Premier League games against United.
N'Golo Kante could make his return from injury for the hosts and he could line up alongside Danny Drinkwater, who would be making his Premier League debut at the club. Victor Moses is the only definite absentee for Conte.
For Jose Mourinho, Paul Pogba, Michael Carrick, Marouane Fellaini, Marcos Rojo and Zlatan Ibrahimovic all remain on the sidelines, while Jesse Lingard picked up a back injury midweek against Benfica.
Potential lineups:
Chelsea: Courtois; Cahill, Luiz, Azpilicueta; Alonso, Drinkwater, Kante, Zappacosta; Hazard, Pedro, Morata.
Manchester United: De Gea; Young, Bailly, Jones, Valencia; Herrera, Matic; Rashford, Mkhitaryan, Mata; Lukaku.