The 25-year-old England captain - whose enthusiasm in training on returning from the ankle injury led him to being described as "an animal" by Spurs manager Mauricio Pochettino - is joined in the starting XI by left-back Danny Rose, who has recovered from illness.
Kane starts alongside Son Heung-Min as Mauricio Pochettino opts for the 5-3-2 formation that worked to such devastating effect in his side's recent 3-0 victory over Dortmund. Spurs can pull to within two points of the top two Manchester City and Liverpool if they beat an in-form Burnley side, who are unbeaten in their last seven Premier League matches.