'Sky Sports' is reporting that the Manchester United and England captain will be unavailable for Jose Mourinho's return to Stamford Bridge due to a muscular injury.
Rooney has not travelled to London with the United squad after sustaining the injury in training.
However, it would have been unlikely for Rooney to start the game and would have most probably been on the bench.
The Red Devils skipper has not started United's last three Premier League games after being dropped for the club's 4-1 victory over Leicester.