An easy win over the newly-promoted side added a new name to his ever-increasing list of Premier League victims, taking his total tally up to 45.
Former Manchester United boss and Wenger's fierce rival Sir Alex Ferguson held the previous record having beaten 44 top-flight teams, but Brighton did not offer much resistance for the Frenchman to claim another victim.
The win also allowed the in-form Gunners to climb towards the business end of the table, while Wenger keeps on breaking records.
45 - Arsene Wenger has now beaten 45 different opponents in the @premierleague, more than any other manager (Alex Ferguson, 44). Stalwart. pic.twitter.com/Jx4KakgPCn
— OptaJoe (@OptaJoe) 1 October 2017