The 26-year-old suffered a knee injury in pre-season and suffered a reaction after playing the first two games of Tottenham's Premier League campaign against Newcastle United and Chelsea.
Although the 26-year-old was hoping to return to the squad for Spurs' Champions League tie with Real Madrid, but he has been forced to rest.
However, it is more likely that he will return to action for the Premier League game with Liverpool on October 22.
Tottenham boss Mauricio Pochettino will assess the state of his players on Tuesday with most of his squad currently away on international duty.
The North London outfit face Bournemouth this weekend, before playing Madrid, Liverpool, West Ham and Manchester United later this month.