The Argentine was handed a start in the game despite Alderweireld having started Spurs' previous 12 games in a row in the Premier League and went on to give the ball away in the build-up to Arsenal's third goal.
Speaking on 'The Debate', Sherwood questioned the decision to start the youngster despite the fact that Alderweireld will almost certainly be leaving the club at the end of the season.
"Hindsight makes it easy to be a football manager when you look at decisions made. I was surprised when I saw Alderweireld wasn't in the starting line-up with Vertonghen," Sherwood said.
"I know that they're looking to the future because Alderweireld almost certainly will not be at the football club next year.
"The young Argentinian boy Foyth has come into the side, struggled a bit and made a few mistakes at Wolves. He made a mistake in the derby at the beginning of last week against Chelsea when he should have given a penalty but he got away with that. Then he made a mistake at the weekend.
"Now I understand Mauricio wants to see if he can play in the big games, give him the confidence and try to stick with him and there comes a time when you're playing in that position, which is a very responsible position on the field, when you make a mistake you invariably get punished at the top level. He's made too many and maybe the boy needs to come out.
"It was a massive game, it's a north London derby and arguably the best centre-half partnership in the country is Alderweireld and (Jan) Vertonghen.
"But it's easy sitting here after the event. Mauricio makes a lot of decisions for that football club and you have to say 99 per cent of them have been correct up to now."