The former midfielder, now a pundit, was asked to give his prediction on '5 Live' panel show 'Robbie savage's Premier League Breakfast' and replied: "One-nil Chelsea".
He was joined by fellow Old Trafford academy graduate Ben Thorley who predicted a 2-1 win for the away side but Scholes countered: ''Tell the truth Ben''.
''When you got to Stamford Bridge when the team is flying and full of confidence, it's always going to be a hard game,'' he remarked.
''Chelsea look very good at the moment, although United can take confidence from the second half against Newcastle. It may have only been against a team second from bottom of the league, but they can grasp on to something.
''There was that penalty and then a fine David De Gea save, so United really could have been 4-0 down at half-time.
''They have to take confidence from that second half which was really good and probably the best of the season.
''But Chelsea is a different story. I just hope we are defensively right and that may then give the forwards a chance to win the game.''
Scholes has been an outspoken critic of Jose Mourinho this season and his latest prediction will come as no surprise, with the former England man unimpressed with how the 'Red Devils' have performed.
Manchester United currently sit in eight place, while Chelsea are level on points with Manchester City and Liverpool at the top of the league.