'Los Che' travel to Manchester for a crucial game in the Champions League group stage, having lost at home to Juventus in the opener.
"It's a team that's not used to going through situations like this, but also the way they're made up they've got some great players, first-class players," Rodrigo said.
"They're not used to going through difficult situation, but I think that's part of the career of a footballer. Sometimes you go through bad times and good times.
"I think everyone in football is here to win and I am sure they will want to turn the situation as soon as they can.
"I am sure they would start tomorrow by trying to beat us, so we have to be concentrated, focused. We've come from a good result at the weekend and we're coming here to get the victory."
His manager's message was more of the same: "Whether it's the best or the worst moment to play them, who knows.
"A big club like this, a team like this, with a manager who is probably one of the most experienced in the world and some extraordinary footballers, with huge investment."