'Los Che' stopped short of taking all three points at Old Trafford, but the Spanish side helped extend United's worst start to a season for 29 years by claiming a point courtesy of a goalless draw.
With the recent reports of clashes between Paul Pogba and manager Jose Mourinho, all eyes were on the Frenchman during the game, which proved unfortunate as he was embarrassed by Piccini.
The midfielder came out to the left flank to cover as the right-back looked to advance but was left on the floor as an ankle-breaking change of pace from the Italian beat him all ends up.
The noise that echoed around Old Trafford said it all as even the home fans were impressed by the incident, with Pogba seemingly continuing to have plenty to prove to both them and Mourinho.