Italian side Napoli need only avoid defeat against Jurgen Klopp's side at Anfield on Tuesday, in order to progress to the knockout stages of the competition at their expense.
Liverpool have to win the encounter, either by a 1-0 scoreline, or by two clear goals to overtake their opponents and progress.
However in spite of not needing to win the match, manager Carlo Ancelotti has insisted that playing for anything less than maximum points is against his side's nature.
He told the media: ""I have lots of memories of Anfield - my last one is a good one because I won the title there with Chelsea. It's going to be a tough, exciting match. We'll go there and play our usual game. It would be counter-productive to try and park the bus. Besides anything else, that's not how we play."
Ancelotti added: "We'll try to boss the game and I'm sure the lads are ready and fired up to give their absolute all. We'll go there with an attacking mindset."
Napoli hold the psychological edge over Liverpool, as they won the reverse tie at home by 1-0 back at the start of October.
Nonetheless their manager has made sure to rest vital players leading up to the tie.
He concluded: "I rotated the squad not just to rest a few legs but also to give playing time to some of the other lads. I need everyone and this is the way forward. The lads who came into the team performed well. They all did good things. This game was a potential banana skin and we cleared it well."