Manchester United v Liverpool - Preview and possible lineups
The 'Red Devils' could see Marouane Fellaini back in the squad after the Belgian has successfully recovered from knee surgery while Eric Bailly is also back from his respective knee problem.
However, Anthony Martial is still dealing with a knock from last week and will most likely be one of seven absentees to miss out on derby, with Zlatan Ibrahimovic (knee), Ander Herrera (thigh) and Daley Blind (malleolar) the most notable ones.
As for the Merseyside club, Andrew Robertson, Jordan Henderson and Georginio Wijnaldum are all back in contention after recovering from their respective injury concerns but the game will come too soon for Nathaniel Clyne as he edges toward full fitness following a back problem.
'Red Devils' manager Jose Mourinho:
"For me it is just a big match with two historical clubs, not just in England - in the world. I still don't look to some matches as a special opponent. It is a big match because we are speaking about some big clubs.
"Of course I want to win. It's a big match, a big opponent. It's the team that's just behind us. It's a team that is already in the Champions League last eight. But, I'm not very good on rivalries, every opponent is a rival for me".
Liverpool head coach Jurgen Klopp:
"If we have to defend there, we have to do so with all we have. It's not a battle of systems or philosophies – just two very good teams facing each other.
"When they attack, I hope all my players are involved. If people want to say that's parking the bus, I'm okay with that.
"There are reasons they have two more points than us. We don't want to show how good we are, we just want a good result."
Did you know?
Jurgen Klopp has the best head-to-head record against Jose Mourinho out of any other manager (W3, D4, L1), his only loss coming during his stint as Borussia Dortmund manager in the Champions League.
Last time round:
It was a lacklustre first fixture between these two sides in October, ending goalless with David De Gea pulling off a remarkable save to deny Joel Matip.
Manchester United: De Gea; Valencia, Bailly, Smalling, Young; McTominay, Matic, Pogba; Lingard, Lukaku, Sanchez.
Liverpool: Karius; Alexander-Arnold, Lovren, Van Dijk, Robertson; Oxlade-Chamberlain, Henderson, Can; Salah, Firmino, Mane.