Tallisman Wilfried Zaha is unlikely to be able to play in the match after only just returning to training, and it seems that Christian Benteke will also not be able to play in the game.
The Belgian striker is suffering from a knee injury that he has had to deal with since pre-season, but the severity of it has not been confirmed.
The injuries to his two prefered striking options means that he will have to call upon the services of Alexander Sørloth.
Having failed to score in the Premier League in eight appearances, Palace fans might be concerned about where the goal threat will come from in the match at John Smith's Stadium.