Matches Last 16 - AFC Champions 2021

End

Last 16

FC Esteghlal

0-2

Al-Hilal SFC

13 SEP 2021

End

Last 16

Nagoya Grampus

4-2

Daegu FC

14 SEP 2021

End

Last 16

Ulsan HD FC

0 (3-2) 0

Kawasaki Frontale

14 SEP 2021

End

Last 16

Istiklol Dushanbe

0-1

Persepolis

14 SEP 2021

End

Last 16

Al-Nassr

1-0

Tractor Sazi

14 SEP 2021

End

Last 16

Sharjah FC

1 (4-5) 1

Al-Wahda

14 SEP 2021

End

Last 16

Jeonbuk Hyundai Motors

1 (4-2) 1

BG Pathum United

15 SEP 2021

End

Last 16

Cerezo Osaka

0-1

Pohang Steelers

15 SEP 2021