Only Nigerian Ahmed Musa retained his place as last season's title heroes returned, including Jamie Vardy and Riyad Mahrez.
Sevilla boss Jorge Sampaoli sprung a surprise by naming Argentine forward Joaquin Correa in his side with Franco Vazquez dropping to the bench.
Starting line-ups for the UEFA Champions League last 16, first leg between Sevilla and Leicester City at the Ramon Sanchez Pizjuan on Wednesday (kick-off 1945 GMT):
Sevilla (3-5-2)
Sergio Rico (captain); Adil Rami, Clement Lenglet, Sergio Escudero; Mariano, Steven N'Zonzi, Samir Nasri, Vitolo, Pablo Sarabia; Stefan Jovetic, Joaquin Correa
Leicester City (4-2-3-1)
Kasper Schmeichel; Danny Simpson, Wes Morgan (captain), Robert Huth, Christian Fuchs; Danny Drinkwater, Wilfred Ndidi; Marc Albrighton, Riyad Mahrez, Ahmed Musa; Jamie Vardy
Referee: Clement Turpin (FRA)