Southampton:
Mario Lemina (hamstring) and Jan Bednarek (head) will face late fitness tests whilst club captain Steven Davis is sidelined with an achilles injury. Don't be surprised to see Manolo Gabbiadini pop up in this tie after his heroics against Swansea on Tuesday.
Manchester City:
Pep Guardiola will have to go without his star striker, Sergio Aguero, who is still recovering from a knee injury. Yaya Touré is likely to make his final appearance in sky blue at St. Mary's.
Southampton boss Mark Hughes:
"The win at Swansea wasn't the final step. The focus and commitment has been unwavering ever since and we'll be ready to go again on Sunday."
Manchester City boss Pep Guardiola:
On the prospect of reaching a Premier League century, Pep said: "We have 97 points, have scored a lot of goals and won a lot of games, that is a consequence of the season we have done. Now we want 100 points and finish this almost perfect season in the Premier League."
Did you know?
If City win, they'll set the record for the most Premier League points picked up on the road (50).
Possible line-ups:
Southampton: McCarthy; Cedric, Stephens, Yoshida, Hoedt, Bertrand; Hojbjerg, Romeu; Tadic, Austin, Redmond.
Manchester City: Ederson; Mendy, Stones, Otamendi, Walker; Fernandinho, De Bruyne, Foden; Sane, Jesus, Sterling.