The German is likely to be haunted by his Champions League final performance until his dying days, with his two errors in Kiev handing the title to Real Madrid.
Since then, Karius has been replaced at Liverpool by Alisson and joined Turkish outfit Besiktas on a two-year loan.
However, there was more than a hint of déjà vu for the beleaguered stopper on Thursday night as he was at fault once again in European competition.
With Malmo on the attack, the ball was worked out to Icelandic midfielder Arnór Ingvi Traustason out on the right. He looked to swing in a cross, with the delivery eventually taking a deflection off Caner Erkin.
Karius looked to be well positioned to deal with the cross, only to flap at it in spectacular fashion.
The Besiktas goalkeeper attempted to paw it away with his right hand, but could only watch on in horror as it cleared him and looped into the far corner.
The mistake is likely to be hard to bounce back from for the former Mainz man, who has admitted to being haunted by what happened to him previously in Kiev.
The goal put the Swedes 1-0 up, with the hosts eventually rounding off the win from the penalty spot.