Italy: The 2006 World Cup winners will have to win here to have a chance of progressing to the next round of the competition, as they sit two points behind their opponents.
The main injury miss for the 'Azzurri' is Federico Bernadeschi, with the Juventus winger picking up a hamstring injury, so Federico Chiesa will likely get the nod.
Portugal: Having a good chance of progressing to the next stage of the competition without the help of Cristiano Ronaldo will be a confidence booster for the side. A win would guarantee their place as group leaders.
Andre Gomes had to pull out of the squad due to injury, while veteran defender Pepe will be suspended because of gaining too many yellow cards.
Roberto Mancini on what he wants from his Italy squad:
"We lost in Portugal by playing a very young team, a defeat that could have been there, but now we have the chance to beat them at San Siro, we have to think about this, then we will see what happens in Portugal-Poland.
“Our first goal is to play a good match, to play well as we did in the last two matches. I want to see a team that attacks above all for the San Siro crowd, a stadium that fills up every time Italy arrives and this is important.”
Portugal boss Fernando Santos on how his team will play in the game:
“We’re not here to play on the counter-attack. They have a lot of possession and are very organised, and are trying to be a lot more attacking.
“We also want to keep the ball a lot, we try to disorganise our opponent. We want to eliminate the space and create problems for Italy."
Did you know?
Portugal have scored just five times in their last 11 trips to Italy.
Italy have the worst shots on goal ratio of the 12 teams in the UEFA Nations League A at just 32%.
None of the last eight games between the two sides have ended in a stalemate.
Prediction: 1-1
Possible lineups:
Italy: Donnarumma; Florenzi, Bonucci, Chiellini, Biraghi; Verratti, Jorginho, Barella; Chiesa, Lasagna, Insigne.
Portugal: Rui Patricio; Cancelo, Fonte, Dias, Rui; Carvalho, Neves, Pizzi; Bernardo Silva, Andre Silva, Bruma.