Santos claimed an entertaining away win in the Copa Libertadores, while Barcelona clinched a dramatic victory on Wednesday.
A brace from Kayke helped Santos to a 3-2 victory at fellow Brazilian side Atletico Paranaense in the first leg of their last-16 tie.
Atletico had taken a seventh-minute lead at the Estadio Durival de Britto e Silva as Nikao's well-placed effort found the bottom corner from 20 yards.
But Kayke, on loan from Japanese club Yokohama F. Marinos, levelled for the visitors with a good finish after being put through by Lucas Lima in the 25th minute.
Santos se impone en su visita al Atlético Paranaense por 3-2.#ConmebolLibertadoresBridgestone pic.twitter.com/4h7y8RYWXp
— CONMEBOL.com (@CONMEBOL) July 6, 2017
Santos took control after the break, but only after some calamitous goalkeeping.
Atletico goalkeeper and Brazil international Weverton somehow spilled what was a tame Victor Ferraz strike from distance, allowing Bruno Henrique to pounce and tap in to make it 2-1.
Santos' third in the 68th minute was far more convincing.
Bruno Henrique turned superbly to make room down the left before crossing for Kayke, who met it with a classy back-heel flick and found the bottom corner.
Ederson pulled a goal back for the hosts four minutes later to give them hope ahead of next month's second leg.
In Guayaquil, Barcelona needed until the 92nd minute to secure a 1-0 win at home to Palmeiras.
Jonathan Alvez struck the winner with some luck, his 30-yard effort taking a huge deflection before rolling into the bottom corner.
Wilstermann claimed a 1-0 victory at home to Atletico Mineiro thanks to Gilbert Alvarez, who scored with an overhead kick in the 41st minute.