With the top two in Serie B automatically promoted, Crotone are 13 points clear of third-place Trapani, who still have four matches to play.
The league-leading Calabrians, who are coached by former Croatia international Ivan Juric, are five points clear of second-place Cagliari who also have a game in hand.
Cagliari are well-placed to join Crotone in the top flight next season, while the third promotion spot will be decided after the play-offs.