Crystal Palace manager Alan Pardew announced that Souare will miss up to six months after breaking his thighbone in a car crash.
He suffered this accident on Sunday in London and will probably leave the hospital in Saturday.
Pardew said: "He isn't having the best of times, but we're all very supportive. We love Pape and can't wait to have him back".
Is injury is expected to heal in a normal period.
Souare joined Palace in January 2015 from Lile and made 46 Premier League appearances for the club.