Having scored seven goals in the first half of the season, Dost has been sidelined since he picked up a fracture during Wolfsburg's winter training camp in Lagos, Portugal.
He missed both legs of Wolfsburg's last-16 clash against Belgium's Gent after the his club had reached the knockout stages for the first time in their history.
But now the 26-year-old is hoping to be fit against Bayer Leverkusen on April 1 having taken part in Wolfsburg training on Tuesday for the first time since his injury.
"Of course, I'd like to play this weekend (against Darmstadt), but I don't think I'll manage that," Dost told Sky.
"The weekend afterwards is an international window and then there's the Leverkusen game -- I must manage that."
Wolfsburg will find out on Friday who they will face in the last 16 of the Champions League when the draw is made in Nyon, with the first leg to be played on April 5/6 with the return on 12/13."