The Colombian's first start under Ernesto Valverde comes at a complicated time, with the need to play alongside Lucas Digne rather than Gerard Pique or Samuel Umtiti due to injury and suspension respectively.
The task for Yerry Mina is a big one. In fact, he will have to be the leader of the defence in one of the strangest defensive lineups in the history of Barcelona. Sergi Roberto, a converted central midfielder, and Digne and Jordi Alba who are both natural left backs, will be his companions in the back four.
Lucas Digne has offered central defence on occasion in the last few months, when the 'Blaugrana' have been affected by other injuries, but he has admitted that he's only played the position "two times" in his life.
The challenge will be difficult for a defence with an average height of 1.78m and surely they will be made to suffer. Amath is quick, but it's the movements of Angel in and around the area that are more reminiscent of a true number 9. Luckily there is no Jorge Molina to contend with.
With Vermaelen and Pique injured, together with an accumulation of yellow cards for Umtiti, Valverde has little other option.
The eyes of Colombia and the world will be on the Nou Camp. It's not a particularly difficult game for the Catalans, who have a healthy lead in the league, even with Atletico Madrid's win on Saturday.
Furthermore, Valverde has been able to rotate further forward. Paco Alcacer has come in next to Messi and Suarez. Busquets and Rakitic behind will give Paulinho some rest so it will fall to Coutinho to run the middle of the park.