All the goals were scored in the second half in Lyon, with Hakimi opening the scoring on 53 minutes and Dembele doubling PSG's lead just before the hour mark. Rayan Cherki pulled one back for the hosts late on to potentially set up a grandstand finish, only for Hakimi to find the net again. Corentin Tolisso then grabbed a second goal for Lyon in stoppage time.
PSG have won 18, drawn five and lost none of their 23 domestic league outings this season and are now a huge 13 points clear of nearest chasers Marseille at the top of the table.
They have not lost a single domestic game this season and have not been beaten at all by French opposition since a 3-1 defeat at home to Toulouse last May.
Luis Enrique's team next travel to Brittany to play fourth-tier Saint-Brieuc in the French Cup quarter-finals on Wednesday, before hosting Lille in Ligue 1 next weekend.
That will be followed by the home leg of their Champions League last-16 showdown with English Premier League leaders Liverpool, scheduled for Wednesday, March 5. Lyon, meanwhile, remain sixth but have now lost two of their four matches under new coach Paulo Fonseca.
This result, while not a surprise, is a blow to their hopes of qualifying for next season's Champions League as they now sit five points adrift of the top four.