Lazio and Galatasaray secured their places in the knockout stages
Lazio and Galatasaray will face off in two weeks' time for top spot in Group E after securing qualification in style.
Lazio were 3-0 winners over Lokomotiv Moscow, who are set to lose head of sports and development Ralf Rangnick to Manchester United according to reports.
Ciro Immobile scored two second half penalties before Pedro Rodriguez rounded off the scoring.
Galatasaray hold a three-point lead at the top of the group after ending Marseille's chances of progress in a 4-2 thriller in Istanbul.
West Ham's fine return to European football continued with a 2-0 win over Rapid Vienna despite David Moyes naming a much-changed line-up.
Andriy Yarmolenko and Mark Noble were on target for the English side.