Tottenham chairman Daniel Levy may be worried about losing manager Mauricio Pochettino.
Unai Emery is wary of asking too much, too soon of Laurent Koscielny following the Arsenal defender's long-awaited return from injury.
AC Milan crashed out of the Europa League after losing 3-1 at Olympiacos in their final Group F game on Thursday.
Aymeric Laporte is impressing in Manchester City's defence, but is yet to make his debut for world champions France.
Alvaro Morata went off injured in first-half stoppage time during Chelsea's 2-2 draw with Vidi in the Europa League.
Barcelona will head to Levante on Sunday night top of La Liga and with a score to settle.
Champions Juventus tackle city rivals Torino with pride at stake as Italy's top teams return to the home comforts of Serie A this weekend licking their wounds after a bruising week in Europe.
Borussia Dortmund can take a significant first step towards breaking Bayern Munich's stranglehold on the Bundesliga title by beating Werder Bremen on Saturday to become 'Herbstmeister', or autumn champions.