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Alexis Sanchez put a miserable club season with Manchester United behind him as he sent Chile into the Copa America quarter-finals with the winning goal in Friday's 2-1 win over Ecuador.
Ecuador were thrashed by Uruguay last time out and must now look to bounce back against two-time defending Copa America champions Chile.
Luis Suarez and Edinson Cavani were on target as Uruguay thumped 10-man Ecuador 4-0 in their opening Group C match at the Copa America on Sunday.
Fifteen-time champions Uruguay begin their latest bid for Copa America glory with a showdown against out-of-form Ecuador in Belo Horizonte.
Ecuador are looking to emulate the success of Giro d'Italia cycling champion Richard Carapaz and "create surprises" at the Copa America in Brazil, central defender Arturo Mina said on Friday.
The Ecuadorian FA has suspended five players over alleged indiscipline ahead of their World Cup qualifying loss to Argentina.
After two years of qualifiers, the latest round confirmed 23 of the 32 teams who will compete in The 2018 World Cup in Russia. While the likes of Ronaldo, Messi or Neymar will feature for their respective countries, some big names will miss out on next summer's showpiece.
Lionel Messi and Cristiano Ronaldo are two of the players at risk of not appearing at the World Cup in Russia next year. We take a look at other top players would could miss out on qualification.
Philippe Coutinho shrugged off his transfer disappointment with a goal as Brazil beat Ecuador to guarantee top spot in South America's 2018 World Cup qualifying race on Thursday while Chile and Argentina stumbled once more.