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Boca Juniors scored four goals against Jorge Wilstermann on Wednesday, after Cruzeiro's Fred celebrated a first-half hat-trick.
Rodriguinho's seventh-minute opener and Jadson's last-gasp strike saw Cruzeiro account for Deportivo Lara in Group B on Wednesday.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
Although he has enjoyed his time back at Cruzeiro, Lucas Silva has not given up on forging a career with Real Madrid.
A second-half goal from Uruguay attacking midfielder Giorgian de Arrascaeta just hours after he returned from international helped Cruzeiro to victory in the Copa do Brasil on Wednesday night, with their 2-1 second-leg win securing a 3-1 aggregate triumph.
Dede was sent off for a collision with Esteban Andrada that fractured the Boca Juniors goalkeeper's jaw, but Mano Menezes was not happy.
Mauro Zarate and Pablo Perez helped Boca Juniors to a win over Cruzeiro in the Copa Libertadores.
Ramon Abila and Mauro Zarate were on target in the first half as Boca Juniors defeated Libertad 2-0 in Buenos Aires.
The group stages of South America's premier club competition has come to an end. Here are the 16 best teams who will battle it out in the quarter-finals after the conclusion of the draw on June 4.
Cruzeiro moved into the Copa Libertadores knockout stage after a win against Racing Club.
Real Madrid loanee Lucas Silva is continuing to profit from his season at Cruzeiro and the Brazilian club is already negotiating a contract extension with the Spanish giants with Silva's return to Europe looking highly unlikely.