Wayne Rooney's fifth goal of the MLS season helped DC United go clear atop the Eastern Conference.
Leroy Sane has not been first choice for Pep Guardiola of late but he produced a game-changing turn from the bench in the Manchester derby.
The gulf between the two Manchester clubs was there for all to see at Old Trafford and Ole Gunnar Solskjaer had no complaints.
Manchester City beat rivals Manchester United 2-0 at Old Trafford to go back in front of Liverpool at the top of the Premier League.
Goals from Bernardo Silva and Leroy Sane condemned Manchester United to defeat in the derby, with Marcus Rashford critical of his side.
Antoine Griezmann is important for the future of Atletico Madrid, coach Diego Simeone said.
Fernandinho is set to have a scan on the knee injury he suffered in Manchester City's derby win over United.
No manager had ever won three consecutive Premier League matches at Old Trafford, with Manchester City's Pep Guardiola breaking new ground.
River Plate progressed to the Copa Libertadores knockout stage after a win at Palestino.
Wayne Rooney fired DC United to the top of Major League Soccer's Eastern Conference standings on Wednesday, scoring the game's only goal in a 1-0 win over Columbus Crew.
England's 20 Premier League clubs amassed record combined revenues of Â£4.8 billion ($6.2 billion) for the 2017/18 season, but saw profitability hit by rising wage bills, according to a report by football finance experts Deloitte.
Manchester City's 2-0 derby victory at Manchester United edged Pep Guardiola's men one point ahead of Liverpool once more in one of the tightest Premier League title races ever.
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