As expected, there are many notable absentees in the squad list for the visit to Fuenlabrada at the Estadio Fernando Torres.
Zidane is giving a rest to the bulk of his team, which is already weighed down by a busy calendar of fixtures at the start of this season.
This means that players who are often on the fringe of the first team will get the opportunity to feature in the starting eleven. Marco Asensio is likely to be the main man, as he features fairly regularly in the first-team setup.
The likes of Lucas Vazquez, Borja Mayoral, Achraf Hakimi and Marcos Llorente will also get the chance to shine.
Here is the full squad list below:
Here's our 16-man squad for tonight's Copa del Rey match against @CFuenlabradaSAD!
— Real Madrid C.F. (@realmadriden) October 26, 2017
#RMMovistar #RMCopa pic.twitter.com/3TRcgQhGKq