After joining United on Monday, Sanchez is in line to make his debut for his new club after Jose Mourinho confirmed the 29-year-old will be at Huish Park, with United set to name a "very strong team" to face the League Two Glovers.
The Portuguese manager will not take any risks as he looks to progress in the FA Cup against the lowest-ranked team left in the competition.
"We want to win," added Mourinho. "We know what cups are. Manchester United played a couple of years ago at Yeovil [in January 2015] and they know the difficulties they felt.
"So we have to go with a very strong team. We are going to rest a couple of players; we also have a couple of problems that we want to try to resolve, with problems for the next matches in February in the Premier League and also Champions League. But it will be a very strong team."
Yeovil manager Darren Way, whose survival story is rather moving, is eager for the challenge, saying: "I want Man United to put out their best team because if we get a result then victory will taste even sweeter."
The hosts will be without former United youngster Otis Khan, who was handed a five-match ban for pushing an official.
Sergio Romero is likely to replace David De Gea in goal, while Zlatan Ibrahimovic (knee) and Eric Bailly (ankle) remain sidelined through injury.
Potential lineups:
Yeovil Town: Krysiak; James, Smith, Sowunmi, Dickson; Gray, Green, Bird, Santos; Surridge, Zoko
Manchester United: Romero; Darmian, Lindelof, Rojo, Shaw; Herrera, Fellaini; Mata, Lingard, Sanchez; Rashford