The 'Three Lions' are in an excellent position to go through to the last four of the Nations League when they play Croatia, with a win guaranteeing their place at the top of the group.
After some an impressive performance against Spain, and a 3-0 domination of the USA earlier in the week, there a lot of contenders for a starting position in the game.
Jadon Sancho has been a revelation for his club this season, and managed to bag an assist in the game against the USA, meaning he could get a starting place on the right wing. Should that happen, it is likely Raheem Sterling would move to the left and Marcus Rasford drop out of the team.
Another position which is hotly contested is central midfield, with Harry Winks, Eric Dier and Ross Barkley putting in excellent performances against Spain while Dele Alli, Jesse Lingard and Jordan Henderson have come back to fitness.
The final isisue Southgate faces is at full-back, with Trent Alexander-Arnold bagging the man of the match award in Thursday's friendly which could put Kyle Walker's position in doubt, while Ben Chilwell and Luke Shaw have had equally impressive seasons so far at left-back for their clubs.