West Ham: The hosts have a few concerns ahead of this one, with Marko Arnautovic having limped off with a knee injury in the win over Everton last weekend and Javier Hernandez struck down by a virus. Midfielder Jack Wilshere will definitely miss out after undergoing minor ankle surgery.
Chelsea: The 'Blues' are expected to recall a host of first-team stars following their Europa League exertions in midweek, though winger Pedro could miss out after injuring his shoulder in that game. Eden Hazard and David Luis should both come back into the side, whilst Mateo Kovacic is expected to shake off a dead leg in time to be fit.
West Ham boss Manuel Pellegrini:
"It's a derby, which has a bit more importance. I know in London there are a lot of them with different teams. We have our first one with Chelsea, who are top of the table, which is big motivation.
"It's impossible to start better than Chelsea have. They've won five games, but every game is different.
"We must be confident at home. We will try to do the same as the last game. We have to concentrate defensively, but I am confident."
Chelsea boss Maurizio Sarri:
"Here, at the moment, I am very happy. I am very happy with the situation, I am very happy with the players, I am very happy with the club.
"I know that the Premier League is very competitive. I know that in the future, probably, I will have to face some difficulties.
"I have seen the five matches of West Ham in the Premier League. I think they are a very good team. I think the position in the table of West Ham is not reality."
Form:
Did you know?
West Ham have only lost two of the last seven meetings between the two sides in all competitions (W3, D2, L2).
West Ham have won three of their last four home games against Chelsea in all competitions.
A Chelsea win will see them win their first six Premier League games of a season for just the third time, with them winning the title on both previous occasions (2005/06 and 2009/10).
Possible lineups:
West Ham: Fabianski; Zabaleta, Balbuena, Diop, Masuaku; Rice, Nopble, Obiang; Yamolenko, Perez, Felipe Anderson.
Chelsea: Kepa; Azpilicueta, Rudiger, David Luiz, Alonso; Kanté, Jorginho, Kovacic; Willian, Giroud, Hazard.