Valencia defender Aymen Abdennour has suffered a hamstring injury, the Liga club have confirmed.
Tunisia international Abdennour sustained the problem during Tuesday night's Champions League clash at Lyon, where he was substituted just before the hour.
A statement on Valencia's official website read: "According to the tests that have been submitted this morning, Abdennour has a muscle injury in the femoral biceps of his left thigh, pending developments."
Nuno Espirito Santo's side won the Group H encounter in France 1-0 thanks to a first-half strike from Sofiane Feghouli, following a defeat to Zenit St Petersburg in the opening round of the Champions League group stage
Abdennour joined Valencia from Monaco last month following Nicolas Otamendi's departure to Manchester City as the Spanish club looked to restructure their defensive ranks for the European campaign.
The 26-year-old started five of Los Che's past six matches, sitting out last Friday's 1-0 win over Granada, becoming an integral part of Nuno's side.