That game against the Swiss started Spain's march to the title, with a shock 1-0 defeat providing 'La Roja' with the shot in the arm they needed to blaze a trail to glory.
Five of the survivors from eight years ago started that game in South Africa, with Ramos starting at right-back in a defence that included Pique and Carles Puyol on that occasion, with the Real Madrid star expected to start alongside Cesar Azpilicueta at centre-half on Sunday.
Busquets had already cemented his position in Spain's midfield, proving key as they cruised to the title, a feat he will be hoping to repeat in Russia.
Back in 2010, Iniesta was considered one of the best players in world football and whilst he failed to have much of an impact against the Swiss, his moment came in the final as he scored the decisive goal in the 116th minute.
Alognside Iniesta in midfielder was David Silva, someone who remains a key part of Julen Lopetegui's side today. The Manchester City star is the top scorer in the current Spain squad and will have a chance to add to that record at the World Cup.
The last survivor from that game didn't actually get on the pitch, with back-up goalkeeper Pepe Reina losing out to captain Iker Casillas in the battle for the gloves.
Whilst Spain have rejuvenated themselves in the eight years since that triumph, there remain a few pillars of the side that was named the best in the world.